The term leukonychia is used to describe nails that appear white. It can be divided into several categories: partial versus complete, true versus apparent, and congenital versus acquired.
True leukonychia occurs when the actual nail plate is white due to alterations of the nail plate keratinocytes. Apparent leukonychia is due to alterations in the nail bed, matrix or hyponychium that give the nail the white appearance.
Punctate leukonychia is common and results from minor nail trauma to the nail in the vicinity of the nail matrix, resulting in nucleated keratinocytes in the nail, which appear as small white areas (Figure 60). An extension of punctate leukonychia is transverse leukonychia, also due to trauma to the matrix, often during manicuring. These narrow white lines are often parallel with the proximal nail fold and grow out with the nail. True leukonychia can be seen in some types of onychomycosis and psoriasis.
Apparent leukonychia describes a nail that looks white but is, in fact, normal in color. Onycholysis is an example of apparent leukonychia because the white appearance is due to air beneath the nail. When the nail is removed in apparent leukonychia, the nail plate is of normal color (Figure 61). Three examples of pseudoleukonychia are Terry’s nail, Muehrche’s lines, and half-and-half nails. These conditions are due to nail bed whitening.
Terry’s nails (Figure 62) appear milky white and opaque from the lunula to the onychodermal band. Terry’s nails are seen in patients with hepatic dysfunction and cirrhosis. There have been reports of Terry’s nails in patients with chronic congestive heart disease, type 2 diabetes mellitus, and aging. The Terry’s nails of congestive heart failure may also be pink, a different presentation from the white nails of liver disease.
Muehrche’s lines (Figure 63) are white horizontal bands that are parallel to the lunula and separated by pink bands. This condition occurs when the serum albumin is low, and disappears when the albumin levels return to normal. Muehrche’s lines occur in patients with renal failure and/or hemodialysis.
The half-and-half nail has a proximal, opaque, white portion that obscures the lunula and a distal red/brown color (Figure 64). It also occurs in patients in renal failure and on hemodialysis.
Other causes of true leukonychia are onychomycosis and psoriasis.
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